![]() The formulation was optimized, leading to a 502-fold increase in solubility of CAR in water as a result of encapsulation within mixed phytomicelles based on DG and RA. This novel nanoformulation of CAR, named CAR pro-phytomicelles, was prepared with rebaudioside A (RA) and dipotassium glycyrrhizinate (DG) as mixed nanomaterials. ![]() Seizures: if prolonged or recurrent – bolus of benzodiazepine.The work describes a novel, small-molecule phytochemicals as nanomaterials based pro-micelles (pro-phytomicelles) drug delivery system, for oral delivery of carvedilol (CAR). Magnesium urgently for any patients with torsades, consider magnesium if prolonged QT prior to development of torsades. Sodium bicarbonate urgently for patient with QRS prolongation and/or severe metabolic acidosis in the lipophilic beta-blockers)Įxtracorporeal membrane oxygenation (ECMO) if unresponsive to above therapiesĬardiac arrest: be prepared for a long (i.e. High dose Insulin Euglycaemic Therapy (HIET) ![]() Glucagon in adults 5-10mg bolus followed by infusion of 50-150 micrograms/kg/hour atenolol, bisoprolol, sotalol).īronchospasm: in overdose systemic effects often seen even with cardioselective beta-blockers.īradycardia: atropine 0.5-1.2 mg in adults if symptomatic, may require pacing. propranolol, metoprolol, carvedilol).ĬNS effects mild in hydrophilic agents (e.g. Sotalol: QT prolongation and increased risk torsade de pointes through mechanism of potassium channel blockade.ĭrowsiness, confusion, seizures, hallucinations, coma – seen with lipophilic beta-blockers (e.g. propranolol) – widening of QRS by blocking Na channels can progress to life-threatening arrhythmias. Clinical Features Of Overdose Cardiovascular:Īgents with membrane stabilising activity (e.g.
0 Comments
Leave a Reply. |
Details
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |